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[edit] Default screen

Each time you start Blender, the default scene is loaded. It looks like the screenshot below.

Don't worry about all those buttons and controls right now! We'll get to them in due time.

You can always quit Blender by pressing Q and clicking on the dialog that says "Quit Blender?" to confirm the quit.

Default screen in Blender. Click image for a larger view.


[edit] One hand on the mouse, one hand on the keyboard

Blender's interface is extremely efficient, and to take advantage of it you'll want to "keep one hand on the mouse and one hand on the keyboard". As you'll see, there are a lot of keyboard shortcuts for speedy workflow. These shortcuts are generally named after the command they execute, so they're easy to remember.

Important
If you make a mistake or something happens that you're not sure of, you can always use Ctrl Z to undo.